CHDH, a key mitochondrial enzyme, plays a diagnostic role in metabolic disorders diseases and tumor progression

Human choline dehydrogenase (CHDH) is a transmembrane protein located in mitochondria. CHDH has been shown to be one of the important catalytic enzymes that catalyze oxidation betaine and involved mitochondrial autophagy after damage. In recent years, an increasing number studies have focused on found close association with pathogenesis various diseases, including tumor prognosis. Here we summarized genomic localization, structure basic functions discuss progress research metabolic disorders other diseases. Moreover, described regulatory role progression different types malignant tumors. addition, major pathogenic mechanisms multiple diseases may associated single nucleotide polymorphism (SNP). We look forward providing new strategies basis for clinical diagnosis prognosis prediction by diagnosing SNP loci genes. Our work evaluates feasibility as molecular marker relevant some tumors, which provide targets treatment related